Antioxidant intervention of smoking-induced lung tumor in mice by vitamin E and quercetin (2025)

Table of Contents
Анотація Список літератури Публікації, які цитують цю публікацію References

Antioxidant intervention of smoking-induced lung tumor in mice by vitamin E and quercetin (1) https://doi.org/10.1186/1471-2407-8-383 · Antioxidant intervention of smoking-induced lung tumor in mice by vitamin E and quercetin (2) Повний текст

Видання: BMC Cancer, 2008, №1

Видавець: Springer Science and Business Media LLC

Автори:

  1. Jie Yang
  2. Lu Wang
  3. Zhaoli Chen
  4. Zhi-Qiang Shen
  5. Min Jin
  6. Xin-Wei Wang
  7. Yufei Zheng
  8. Zhi-Gang Qiu
  9. Jing-feng Wang
  10. Jun-Wen Li

Анотація

Abstract <jats:sec> Background Epidemiological and in vitro studies suggest that antioxidants such as quercetin and vitamin E (VE) can prevent lung tumor caused by smoking; however, there is limited evidence from animal studies. </jats:sec> <jats:sec> Methods In the present study, Swiss mouse was used to examine the potential of quercetin and VE for prevention lung tumor induced by smoking. </jats:sec> <jats:sec> Results Our results suggest that the incidence of lung tumor and tumor multiplicity were 43.5% and 1.00 ± 0.29 in smoking group; Quercetin has limited effects on lung tumor prevention in this in vivo model, as measured by assays for free radical scavenging, reduction of smoke-induced DNA damage and inhibition of apoptosis. On the other hand, vitamin E drastically decreased the incidence of lung tumor and tumor multiplicity which were 17.0% and 0.32 ± 0.16, respectively (p &lt; 0.05); and demonstrated prominent antioxidant effects, reduction of DNA damage and decreased cell apoptosis (p &lt; 0.05). Combined treatment with quercetin and VE in this animal model did not demonstrate any effect greater than that due to vitamin E alone. In addition, gender differences in the occurrence of smoke induced-lung tumor and antioxidant intervention were also observed. </jats:sec> <jats:sec> Conclusion We conclude that VE might prevent lung tumor induced by smoking in Swiss mice. </jats:sec>

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Antioxidant intervention of smoking-induced lung tumor in mice by vitamin E and quercetin (2025)

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